Read this leaflet carefully before you start taking this medicine.  (DOWNLOAD)

• If you have any further questions, ask your health care provider.
• This medicine has been prescribed for you only. Do not pass it on to others. It may harm
them, even if their symptoms are the same as yours.
• If any of the side effects become serious, or if you notice any side effects not listed in this
leaflet, please inform your health care provider.
In this leaflet:
1. What Cisatracurium Injection is and what it is used for
2. What you need to know before you use Cisatracurium Injection
3. How to use Cisatracurium Injection
4. Possible side effects
5. How to store Cisatracurium Injection
6. Contents of the pack and other information
1. WHAT CISATRACURIUM INJECTION IS AND WHAT IT IS USED FOR
Cisatracurium Besylate is used to:
• Relax muscles during anaesthesia for all types of surgical operations on adults and
children over 1 month of age
• Help to insert an endotracheal tube into the trachea means windpipe (endotracheal
intubation), to provide oxygen and anaesthetic gases throughout the surgery.
• Relax the muscles of a patient who is on ventilator in intensive care.
Ask your doctor if you need further explanation about this drug.
2. WHAT YOU NEED TO KNOW BEFORE YOU USE CISATRACURIUM INJECTION
If you are likely to undergo a surgery under general anaesthesia using muscle relaxant
talk to your doctor if in the past you had any one of the following conditions:
• Muscle weakness, tiredness or difficulty in co-ordinating your movements (myasthenia
gravis)
• Neuromuscular disease, such as a muscle wasting disease, paralysis, motor neuron
disease or cerebral palsy
• Burns which required medical treatment.
• An allergic reaction to any muscle relaxant which was given as part of anaesthesia.
Other medicines and Cisatracurium Injection
Cisatracurium Injection may affect other medicines or be affected by them. Tell your
anaesthetist if you are taking, have recently taken or might take any other medicines.
Some medicines reduce the effect of Cisatracurium Injection.
Inform your doctor if you are taking or have recently taken any of the following
medicines:
• Anaesthesia of any type in the past
• Antibiotics (used to treat infections)
• Drugs for irregular heartbeat (anti-arrhythmic)
• Drugs for high blood pressure
• Diuretic drugs, such as Furosemide
• Drugs for inflammation of the joints, such as Chloroquine or Penicillamine
• Steroids
• Drugs for fits (epilepsy), such as Phenytoin or Carbamazepine
• Drugs for mental illness, such as Lithium or Chlorpromazine
• Drugs containing Magnesium
• Drugs for Alzheimer’s disease (anticholinesterases e.g. Donepezil).
• Any herbal products or medicines bought without a prescription.
Pregnancy and breast-feeding
If you are pregnant or breast-feeding OR if you think that you may be pregnant or are
planning to have a baby, please inform your doctor.
Driving and using machines
Do not drive when taking Cisatracurium Injection
3. HOW TO TAKE CISATRACURIUM INJECTION
You will never be expected to take this medicine by yourself. It will always be given to
you by an anaesthesiologist.
Cisatracurium Injection can be given:
As a single injection into your vein (intravenous bolus injection) OR
Your doctor will decide about how, when and how much dose of drug to be given to you.
The dose will depend on:
• Your body weight
• Duration of surgery.
• Your expected response to the medicine.
• Children less than 1 month old should not be given this medicine.
4. POSSIBLE SIDE EFFECTS
Like all medicines, this medicine can cause side effects, although not everybody gets
them.
Allergic reactions are observed in less than 1 in 10,000 individuals which include:
• Sudden wheeze, chest pain or tightness in the chest
• Swelling of eyelids, face, lips, mouth or tongue
• Lumps, rash or ‘hives’ on any part of the body
• Sudden collapse
If these side effects occur while you are under anesthesia, they will be seen and treated
by your anaesthetist.

Adverse Reactions
In the literature, bradycardia, hypotension, flushing, bronchospasm, wheezing,
laryngospasm, rash, muscle weakness and myopathy have been described as adverse
reactions. Hypersensitivity reactions including anaphylactic or anaphylactoid reactions
have been reported.
5. HOW TO STORE CISATRACURIUM INJECTION
• Keep this medicine out of the sight and reach of children.
• Store in a refrigerator (2°C – 8°C). Do not freeze.
• Do not use Cisatracurium Injection after the expiry date which is stated on the carton
and label after ‘EXP’. The expiry date refers to the last day of that month.
6. FURTHER INFORMATION.
What CISATRACURIUM INJECTION contains
Each ml of Cisatracurium Injection contains 2mg of Cisatracurium Besylate.
What CISATRACURIUM INJECTION looks like and contents of the pack?
Clear transparent liquid in 10x10ml Ampoules packed in an inner carton