PATIENT INFORMATION LEAFLET: INFORMATION FOR THE USER             (PDF DOWNLOAD)

• Keep this leaflet. You may need to read it again before, during or after use of this medicine. • If you have any further questions, ask your healthcare provider. 
• This medicine has been prescribed for you only. Do not pass it on to others. It may harm them,  even if their symptoms are the same as yours. 
• If any of the side effects become serious, or if you notice any side effects not listed in this  leaflet, please inform your health care provider. 

In this leaflet: 

1. What Histin-10 Injection is and what it is used for 
2. What you need to know before you take Histin-10 Injection 
3. How to use Histin-10 Injection 
4. Possible side effects 
5. How to store Histin-10 Injection 
6. Contents of the pack and other information 
7. WHAT HISTIN-10 INJECTION IS AND WHAT IT IS USED FOR 

Histin-10 Injection contains the active ingredient chlorpheniramine maleate which is an antihistamine. This medicine inhibits the release of histamine into the body that occurs during an allergic reaction. This product relieves some of the main symptoms of a severe allergic reaction. 

2. WHAT YOU NEED TO KNOW BEFORE YOU TAKE HISTIN-10 INJECTION Do not take Histin-10 Injection if you: 

• are allergic to Chlorpheniramine. 
• are in a pre-coma state. 
• have had monoamine oxidase inhibitor (MAOI). 
• Have been on anti-depressant treatment within the past 14 days. 

Take special care with Histin-10 Injection 

You should tell your doctor before you are given this product if you: 

• Are being treated for an overactive thyroid or enlarged prostate gland 
• Have epilepsy, glaucoma, very high blood pressure, heart, liver, asthma or chest diseases. 

Taking other medicines 

Please tell your doctor or pharmacist if you are taking or have recently taken any other  medicines, including medicines obtained without a prescription. 

The following affect the way Histin-10 Injection works: 

• MAOIs – these must not be given with Chlorpheniramine.

PATIENT INFORMATION LEAFLET: INFORMATION FOR THE USER 

HISTIN-10 INJECTION 

Chlorpheniramine 10mg/ml 

Histin-10 Injection may increase the effects of the following: 

• Drugs that treat anxiety or help you to sleep (e.g. benzodiazepines) 
• Alcohol 
• Psychotropic drugs (that change perception or behaviour) 
• Atropine 
• Phenytoin (for epilepsy). 

Pregnancy and breast-feeding 

Tell your doctor before using any medicine. Chlorpheniramine must not be given during pregnancy or breastfeeding unless your doctor believes it is essential. 

Driving and using machines 

Histin-10 Injection may cause drowsiness and make you sleepy. Do not drive or operate machinery until you know how this product affects you. 

3. HOW TO TAKE HISTIN-10 INJECTION 

This injection is usually given to you by your doctor or someone else trained to give it to you.  You will be given the injection beneath your skin, or into a muscle, or directly into a vein. 

• Adults: The usual dose is 10mg – 20mg (1 or 2 ampoules), up to a maximum of 40mg (4  ampoules) in 24 hours. 
• Children: The dose will be calculated by the doctor, according to the child’s age or body  weight:

The doctor may dilute chlorpheniramine with sodium chloride 0.9% to make it easier to measure  and inject the small amounts required for children. 

When administered into a vein, the injection should be given slowly over a period of one minute  to avoid a fall in blood pressure (hypotension) or central nervous system stimulation. 

If you are given more Histin-10 Injection than you should 

This product will be given to you under medical supervision. It is therefore unlikely that you will  be given too much. However, if you feel unwell, you should tell your doctor immediately. 

Symptoms of overdose include sedation, seizures, stopping of breathing (apnoea), convulsions, abnormal and sustained muscle contractions (dystonic reactions) and heart failure  (cardiovascular collapse). 

If you have any further questions on the use of this product, ask your doctor or pharmacist. 

4. POSSIBLE SIDE EFFECTS 

Like all medicines, this medicine can cause side effects, although not everybody gets  them. 

The most common side effect is sedation, which can range from slight drowsiness to deep sleep. 

The following side effects have been reported: 

• A stinging or burning feeling at the site of injection. 
• Giddiness or drowsiness if the drug is injected too quickly into a vein (this usually passes) • Nausea, vomiting, or diarrhoea 
• Feeling dizzy, weak, tired, unable to concentrate 
• Rapid or irregular heartbeat, chest tightness, fall in blood pressure. 
• Dryness of the mouth, headache, anorexia, indigestion, abdominal pain, liver problems  including jaundice, difficulty passing urine 
• Muscular incoordination, ringing in the ears, blurred vision, irritability, depression, nightmares • Allergic reactions (skin reactions, itching of raised bumps on the skin, sensitivity to light) • Blood abnormalities. 
• Elderly people may become confused, and children may become excitable. 

If any of these side effects get serious, or if you notice any side effects not listed in this leaflet,  please tell your doctor. 

Reporting of side effects 

If you get any side effects, talk to your healthcare provider. This includes any possible side effects not listed in this leaflet. By reporting side effects, you can help provide more information on the safety of this medicine. 

5. HOW TO STORE HISTIN-10 INJECTION 

• Keep all medicines out of the reach of children. 
• Store below 30˚C. 
• Do not take this medicine after the expiry date ‘Exp. Date’ which is stated on the label. The  expiry date refers to the last day of that month. 

Do not throw away any medicine via wastewater or household waste. Ask your pharmacist how to throw away the medicines you no longer use. These measures will help protect the environment.

 

6. FURTHER INFORMATION 

What HISTIN-10 INJECTION contains 

Each ml of Histin-10 Injection contains 10mg of Chlorpheniramine. 

What HISTIN-10 INJECTION looks like and what contents of the pack 

Histin-10 Injection is packed as 10x1ml ampoule, placed in a carton with patient information  leaflet.